Kupffer cells: increasingly significant role in nonalcoholic fatty liver disease

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Kupffer cells: increasingly significant role in nonalcoholic fatty liver disease.

Non-alcoholic fatty liver disease (NAFLD) is considered to be a manifestation of liver metabolic damage and is related to insulin resistance and genetic susceptibility. Inflammation mediated by Kupffer cells (KCs) is of critical importance to the development of NAFLD. The primary role of KCs in NAFLD is considered to be the perturbation of the C-Jun N-terminal kinase (JNK) and nuclear factor-ka...

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Nonalcoholic Fatty Liver Disease Treatment

Nonalcoholic fatty liver disease (NAFLD) is increasing in pediatric age group parallel to the growing prevalence of obesity and overweight all around the world. So changing in life style and   interventions on obesogenic environment is cornerstone of NAFLD therapy in obese children. Some experts recommend that children and adolescents be encouraged to follow a low-fat, low-glycemic-index diet t...

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Nonalcoholic fatty liver disease: an increasingly common cause of liver disease among HIV-infected persons?

Nonalcoholic fatty liver disease (NAFLD) is an increasingly recognized condition in the general population worldwide. Although data on the prevalence of NAFLD among HIV-infected persons are currently limited, this clinical entity may be a common cause of liver disease in this group. A case of liver dysfunction due to NAFLD in an HIV-infected patient is presented along with a review of the liter...

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Role of bioactive fatty acids in nonalcoholic fatty liver disease

Nonalcoholic fatty liver disease (NAFLD) is characterized by fat deposition in hepatocytes, and a strong association with nutritional factors. Dietary fatty acids are classified according to their biochemical properties, which confer their bioactive roles. Monounsaturated fatty acids have a dual role in various human and murine models. In contrast, polyunsaturated fatty acids exhibit antiobesit...

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Role of liver biopsy in nonalcoholic fatty liver disease.

Nonalcoholic fatty liver disease (NAFLD), defined as abnormal accumulation (> 5%) of hepatic triglyceride without excess alcohol intake, is the most common form of chronic liver disease in adults and children in the United States. NAFLD encompasses a spectrum of histologic findings including uncomplicated steatosis, steatosis with inflammation and steatohepatitis [nonalcoholic steatohepatitis (...

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ژورنال

عنوان ژورنال: Annals of Hepatology

سال: 2014

ISSN: 1665-2681

DOI: 10.1016/s1665-2681(19)31247-5